Tumour Microenvironment

Like any other cells in the body, tumour cells are influenced by blood vessels and the normal cells and molecules that surround and feed the tumour cells – the tumour microenvironment. In order to become established and to grow and spread, tumours need to develop specific capabilities: they must be able to move; remove obstructions to their growth and movement, such as the surrounding extracellular matrix; overcome the immune system and blood-borne cells of the immune system so that they can survive in blood vessels; and establish successfully in their new tissue environment.

In order to achieve these functions, tumours recruit host machinery and proteins involved in normal cell growth including transcription factors. The tumour microenvironment provides the signals that activate transcription factors. Therefore understanding how the tumour microenvironment affects cancer cell behaviour and how it contributes to a cancer cell’s response to ionising radiation is essential in understanding how to prevent the establishment, growth and progression of cancers and how to exploit the tumour microenvironment for therapeutic gain.

Radiopharmaceuticals and Molecular Imaging Group

We aim to develop new radioisotope-labelled compounds for the imaging of tumour biology.

Tumour Hypoxia Group

We are investigating how tumours survive in conditions which include low oxygen (hypoxia). Our...

Hypoxia and Angiogenesis Group

The focus of the group is on tumour angiogenesis and the role of notch signalling, and hypoxia...

Director, CRUK/MRC Oxford Institute for Radiation Oncology. Molecular Resistance to Treatments Group

Our research links basic science with clinical applications and focuses on understanding the...

Mechanisms of Metastasis Group

We are interested in the mechanisms underlying the development of metastasis, the spread of...

Cell Signalling Group

Our research aims to understand the cell and molecular biology behind frequent tumour mutations...

Lung Cancer Research Group

Our group aims to identify novel therapies that target subgroups of lung cancer patients...

Anticancer Viruses and Cancer Vaccines Group

The aim of our research is to design and develop innovative cancer killing viruses and oncolytic...

Experimental Neuroimaging Group

Our goals are to identify the role of the inflammatory and metabolic microenvironment in brain...

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