Director: Professor Keith Channon

The NIHR Oxford Biomedical Research Centre (BRC) brings together the research expertise of the University of Oxford and the clinical skills of the Oxford University Hospitals NHS Trust to support translational research and innovation to improve healthcare for patients. It is made up of 14 research themes covering all areas of therapy.

The Cancer Theme, led by Department of Oncology Professors Mark Middleton and Adrian Harris, aims to develop new treatments or combinations of treatments through the concepts of synthetic lethality and oncogenic vulnerability. It has established the infrastructure to deliver a wide portfolio of academic multi-centre early phase studies involving subsets of patients, and to perform detailed analyses of tumours before, during and after intervention to select patients.