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DPhil Projects

Details of DPhil project topics on offer with links to the interests of the supervisors can be found below.

A Gastrointestinal Epithelial Organoid Assay to Identify Non-Toxic Chemoradiation Combinations for Cancer Treatment
Supervisors: Anne Kiltie, Anderson Ryan
 
A STING in the Tail for Cancer
Supervisors: Peter McHugh, Adrian L Harris.
 
Characterisation of DNA-protein crosslink proteolysis repair
Supervisors: Kristijan Ramadan, Benedikt Kessler.
 
Cross-presentation of exogenous ROP proteins by antigen presenting cells to MHC class I and class II pathways
 
Deciphering the regulation of non-coding RNAs in a hypoxic tumour microenvironment
Supervisors:Francesca Buffa, Adrian Harris
 
Determinants of Sensitivity to G-Quadruplex-Binding Compounds
Supervisors: Madalena Tarsounas, Anderson Ryan
 
Development of Tracers for Real-Time Endoscopic Optical Imaging for Early Detection of Oesophageal Cancer
Supervisors: Kate Vallis, Boris Vojnovic.
 
Dissecting the Determinants of Response to Checkpoint Inhibitors
Supervisors: Benjamin Fairfax, Mark Middleton.
 
Efficient homing of natural killer
 
Enhancing Radiotherapy Outcomes for Oesophageal Cancer
Supervisors: Maria Hawkins, Frank Van den Heuvel
 
Exploiting Clonal Cell Variation to Identify Novel Targets to Enhance the Effects of Radiation in Cancer Therapy
Supervisors: Anderson Ryan, Maria Hawkins
 
Hypoxia-Targeted Protein-Targeting Chimeras (htPROTACS)
Supervisors: Ester Hammond, Stuart Conway.
 
Investigating the Contribution of IGF-1 to Risk of Developing Prostate Cancer
Supervisors: Val Macaulay, Ian Mills.
 
Investigating the Potential Benefits of MRI-LINAC for Delivery of Stereotactic Ablative Radiotherapy (SBRT) in Hepatobiliary Malignancies
Supervisors: Maria Hawkins, Frank Van den Heuvel.
 
Investigating the role of Ribonucleotide Reductase (RNR) in cell physiology and cancer
Supervisors: Vincenzo D’Angiolella, Ross Chapman
 
Mathematical reconstruction of cancer networks
Supervisors: Francesca Buffa, Julio Saez-Rodriguez.
 
Molecular imaging of DNA damage repair
Supervisors: Bart Cornelissen, Nicola Sibson
 
Targeting telomere maintenance pathways in cancer
Supervisors: David Clynes, Andrew Blackford.
 
The IGF axis as a mediator of treatment resistance in glioblastoma multiforme
Supervisors: Val Macaulay, Nicola Sibson.
 
Understanding Epigenetic Control to Develop Novel Cancer Drugs
Supervisor: Nick La Thangue
 
Understanding How DNA Repair Pathway Choice is Controlled
Supervisors: Andrew Blackford, David Clynes
 
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