We study the signalling mechanisms cells use to respond to DNA damage and why defects in these...
Title
DNA Damage & Repair
DNA contains the essential genetic information in living cells. When cells grow and divide they need to ensure correct replication of DNA and to repair any mistakes or mutations. Accumulation of these mutations if not properly repaired can lead to uncontrolled cell growth that is the hallmark of cancer. Understanding DNA damage and repair mechanisms helps researchers to identify the aberrant processes that drive cancer development and growth.
Nucleic Acids Research Group
We design and synthesise chemically modified DNA for diagnostic and therapeutic applications....
Cancer therapeutics, DNA damage and repair laboratory
A major focus of our work is exploring how ATRX prevents normal cells from elongating their...
Cell Cycle and Ubiquitin Signalling
Our group objective is to understand the role of the ubiquitin system in cancer cell survival...
Biochemistry and Regulation of DNA Repair Group
My interests over the years have focussed on the proteins and mechanisms involved in the...
Genomics of Inflammation and Cancer Immunology
We are interested in the genetic and epigenetic determinants of inter-individual variation in...
Chromosome Integrity Group
The aim or our research is to understand how genome stability is maintained in response to DNA...
DNA Repair in Cancer Treatment Group
We are investigating DNA damage signalling and repair factors in bladder cancer to develop new...
Cancer Cell Cycle Group
Research in Nick La Thangue’s group focusses on the mechanisms that give rise to the abnormal...
DNA Damage and Repair Group
We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and...
DNA Damage Response Group
We are interested in the role of the ubiquitin-proteasome system in DNA repair, ageing, cancer...
Genome Stability and Tumourigenesis Group
Our research is focused on gaining a greater understanding of how homologous recombination (HR...
About Us
We aim to enhance clinical and basic cancer research in Oxford with the ultimate goal of increasing cancer cure rates.
Research
In Oxford, we have a great wealth of broad-ranging expertise and a powerful network of cancer researchers.
Study With Us
Our graduate training programmes for both scientists and clinicians are internationally recognised.